Author

Meghan W. Sedovy

Carilion Roanoke Memorial HospitalORCID 0000-0001-9477-8240Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Angela K. Best· 2 shared Brant E. IsaksoniD· 2 shared Clare L. DennisoniD· 2 shared Kailynn RobertsiD· 2 shared Mark C. RentoniD· 2 shared Melissa R. LeafiD· 2 shared Paul D. LampeiD· 2 shared Scott R. JohnstoneiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Angela K. Best

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Injury Induced Connexin 43 Expression Regulates Endothelial Wound Healing

Meghan W. Sedovy, Mark C. Renton, Kailynn Roberts, Xinyan Leng, Clare L. Dennison, Caroline O Toler, Melissa R. Leaf, Paul D. Lampe, Angela K. Best, Brant E. Isakson, Scott R. Johnstone

This study shows that injury-induced Cx43 upregulation in endothelial cells promotes wound healing through gap junction-mediated communication, with phosphorylation playing a key role.

American Journal of Physiology-Heart and Circulatory Physiology · Oct 8, 2025Peer-reviewedPhysiology

A connexin 43 targeting peptide prevents blood vessel neointima formation

Mark C. Renton, Meghan W. Sedovy, Xinyan Leng, Farwah Iqbal, Melissa R. Leaf, Kailynn Roberts, Ramya C. Joshi, Arya Malek, Clare L. Dennison, Angela K. Best, Paul D. Lampe, Joseph W. Baker, Mark Joseph, George S. Baillie, Brant E. Isakson, Scott R. Johnstone

This study identifies a Cx43 targeting peptide that inhibits neointima formation in both human and mouse models by blocking cyclin E interactions and cell cycle progression.

bioRxiv · Sep 22, 2025 · PreprintPhysiology