Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria
Nuri K. Hegelmeyer, Lia A. Parkin, Mary Lou Previti, Joshua Andrade, Raditya Utama, Richard Sejour, Justin Gardin, Stéphanie Muller, Steven Ketchum, Alisa Yurovsky, Bruce Futcher, Sara Goodwin, Beatrix M. Ueberheide, Jessica C. Seeliger
The paper shows that synonymous mutations in mycobacteria can create new transcription start sites within genes, leading to smaller protein isoforms.
mBio · Oct 3, 2023Peer-reviewedMolecular Biology