Lysosomal reduced thiols are essential for mouse embryonic development
Charles H. Adelmann, Avanthika Venkatachalam, Lingjuan Huang, Michelle Liu, Sharon K. Germana, Stefan Andrew Harry, Paul C. Rosen, Joshua Herron, Pei-Chieh Tien, Liron Bar‐Peled, David M. Sabatini, David E. Fisher
This study shows that MFSD12 is essential for mouse embryonic development by supplying reduced cysteine to lysosomes, and cysteamine treatment rescues Mfsd12 knockout mice.
Proceedings of the National Academy of Sciences · Sep 2, 2025Peer-reviewedCell Biology