The primary sclerosing cholangitis and ulcerative colitis colonic mucosa defined through paired microbial and single-cell RNA sequencing
Jacqueline L.E. Tearle, Ekaterina N. Sviriaeva, F C Zhang, Katherine Jackson, Joshua Kaye, Pedram Tavakoli, Sabrina Koentgen, Joanna Warren, Raymond R. Liang, Pratibha Malhotra, Cameron Williams, Ashraful Haque, Arteen Arzivian, Kotlapati Sudhakar, Drew R. Neavin, , Kylie Renee James
This study identifies distinct cellular and microbial profiles in PSC-UC and UC patients using single-cell and spatial transcriptomics, revealing shared and unique inflammatory mechanisms.
Nature Communications · Jul 7, 2026Peer-reviewedCell Biology