Author

Jacqueline L.E. Tearle

Garvan Institute of Medical ResearchORCID 0000-0001-7464-6187Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Kylie Renee JamesiD· 3 shared Aleksandra A. KolodziejczykiD· 1 shared Ana ÍzcueiD· 1 shared Andreas B. WildiD· 1 shared Andrew Kim· 1 shared Arteen ArzivianiD· 1 shared Ashraful HaqueiD· 1 shared Asmae Laouina· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

Kylie Renee JamesORCID

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3 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedJul 7, 2026

The primary sclerosing cholangitis and ulcerative colitis colonic mucosa defined through paired microbial and single-cell RNA sequencing

Jacqueline L.E. Tearle, Ekaterina N. Sviriaeva, F C Zhang…·Kylie Renee James

This study identifies distinct cellular and microbial profiles in PSC-UC and UC patients using single-cell and spatial transcriptomics, revealing shared and unique inflammatory mechanisms.

1 citation

humanscRNA-seq

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ImmunologybioRxivPreprintMar 15, 2026

Tumors accumulate expanded GATA3-dependent tissue Tregs

Katharina Kunesch, Sraddha S. Bharadwaj, Jacqueline L.E. Tearle…·Ana Ízcue

The paper shows that tumors drive the accumulation of GATA3-dependent effector tissue Tregs through TCR-dependent oligoclonal expansion, promoting tumor growth.

DOI 10.64898/2026.03.13.707380

mouseexperimental assay

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GenomicsMolecular Biology and EvolutionPeer-reviewedJan 18, 2025

Spatial and single-cell transcriptomics illuminate bat immunity and barrier tissue evolution

Roy Levinger, Dafna Tussia-Cohen, Sivan Friedman…·Tzachi Hagai

This study uses spatial and single-cell transcriptomics to compare bat, mouse, and human tissues, revealing immune pathway divergence and unique gene expression patterns in bat gut and lung.

18 citationstop 1%

mousehuman

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