Katherine Jackson

Single-cell multi-omics maps clonal IEL expansion and epithelial remodelling in refractory coeliac disease

This study identifies clonal IEL expansion and epithelial remodelling in RCD1 using single-cell multi-omics, showing distinct immune and epithelial states compared to ACD.

The primary sclerosing cholangitis and ulcerative colitis colonic mucosa defined through paired microbial and single-cell RNA sequencing

This study identifies distinct cellular and microbial profiles in PSC-UC and UC patients using single-cell and spatial transcriptomics, revealing shared and unique inflammatory mechanisms.

Both T and B cells contribute to dysregulated activation and differentiation of CD4+ T cells in Activated PI3K delta syndrome 1

This study investigates the role of PI3K GOF in APDS1, showing that T and B cells contribute to dysregulated T cell activation and differentiation through extrinsic mechanisms.

Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire

The paper shows that genetic variation in the immunoglobulin heavy chain locus influences the diversity and characteristics of the human antibody repertoire.

High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes

This paper introduces RAGE-seq, a method combining long-read and short-read sequencing to analyze lymphocyte clonal and transcriptional features in breast cancer tissues.