Kylie Renee James

This study identifies distinct cellular and microbial profiles in PSC-UC and UC patients using single-cell and spatial transcriptomics, revealing shared and unique inflammatory mechanisms.

The paper shows that tumors drive the accumulation of GATA3-dependent effector tissue Tregs through TCR-dependent oligoclonal expansion, promoting tumor growth.

This study shows Malat1 regulates cytokine expression in female Th2 cells by affecting early differentiation and IL2 response, but not in male cells.

This study uses spatial and single-cell transcriptomics to compare bat, mouse, and human tissues, revealing immune pathway divergence and unique gene expression patterns in bat gut and lung.

The paper integrates single-cell RNA-seq datasets across the GI tract to identify epithelial metaplasia in inflammatory diseases, showing its role in inflammation through immune cell interactions.