ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation
Hyogon Sohn, Ana Kolicheski, Jennifer Poursine‐Laurent, Jennifer Tran, Yongjun Wang, Kelly Gan, Joshua M Tobin, Nermina Saucier, Todd A. Fehniger, Jacqueline E. Payton, Megan A. Cooper
This study shows ACLY supports NK cell effector functions by regulating glycolysis and histone acetylation, with acetate supplementation restoring these functions in ACLY-deficient cells.
The Journal of Immunology · Aug 25, 2025Peer-reviewedImmunology