Todd A. Fehniger

Personalized Neoantigen Vaccines Synergize with Immune Checkpoint Therapy and CD8-Targeted Cytokines to Control B-Cell Lymphoma

This study shows that personalized neoantigen vaccines combined with immune checkpoint therapy and CD8-targeted cytokines effectively control B-cell lymphoma by enhancing T-cell responses and preventing dysfunction.

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma

The paper characterizes immune microenvironment dysregulation in multiple myeloma using single-cell data and links it to disease progression and patient outcomes.

ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation

This study shows ACLY supports NK cell effector functions by regulating glycolysis and histone acetylation, with acetate supplementation restoring these functions in ACLY-deficient cells.

Neoantigen Landscape Supports Feasibility of Personalized Cancer Vaccine for Follicular Lymphoma

This study identifies high-quality neoantigens in follicular lymphoma patients using WES and RNA-Seq, and initiates a clinical trial of personalized neoantigen vaccines combined with PD-1 blockade.

Single Cell T Cell Receptor Repertoire Profiling for Dogs

This paper develops species-specific single-cell T cell receptor sequencing (scTCRseq) for dogs, enabling analysis of T cell repertoires in cancer immunotherapy trials.

Ultra Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma

This study uses ultra-deep exome sequencing to identify recurrent mutations in classical Hodgkin lymphoma HRS cells, demonstrating its utility for analyzing genomic variants in large patient cohorts.

Computational prediction of MHC anchor locations guide neoantigen identification and prioritization

The paper predicts MHC anchor positions for 328 HLA alleles and shows that incorporating these improves neoantigen identification by correcting misclassified candidates in tumor samples.

Identification of community-consensus clinically relevant variants and development of single molecule molecular inversion probes using the CIViC database

The paper designs single molecule molecular inversion probes targeting clinically relevant variants using the CIViC database, demonstrating high sensitivity and discovering missed variants in cancer samples.