ClpXP Overexpression Boosts Mitochondrial Protein Degradation, Organismal Health, and Longevity Without Altering Stress Response in D. melanogaster
Camille Goldman, Chadinthon Kittivorawong, Samantha Salazar, Paul M. Oh, Kristofer Chang, Muhammad Jalal, Patcharapitcha Pechkamnerd, Tracy Han, Aly Rajan, Joshua Zhong, Malina DiBlasi, Jae H. Hur
This study shows that overexpressing ClpXP in Drosophila enhances mitochondrial protein degradation, improves health, and extends lifespan without affecting stress responses.
bioRxiv · Aug 25, 2026 · PreprintCell Biology