Camille Goldman

ClpXP Overexpression Boosts Mitochondrial Protein Degradation, Organismal Health, and Longevity Without Altering Stress Response in D. melanogaster

This study shows that overexpressing ClpXP in Drosophila enhances mitochondrial protein degradation, improves health, and extends lifespan without affecting stress responses.

Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout

The paper develops GEM-SCOPe, a modular fluorescent tool to study lysosomal and mitochondrial dysfunction in Parkinson's disease, identifying disease-related changes in organelle behavior.

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue Model

This study develops a human brain tissue model (miBrain) to show that APOE4 astrocytes with cholesterol dysregulation promote α-synuclein pathology through endolysosomal dysfunction.

Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model.

This study shows that impaired lysosomal proteolysis in astrocytes leads to proteostasis failure in midbrain neurons in an early-onset PD model.