Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis
Jake N. Lichterman, Tarun Srinivasan, Ruheng Wang, Chaitanya Dende, Christina M. Zarek, Josue I. Ramirez, Noheon Park, Hesuiyuan Wang, Wenling Li, Jiwoong Kim, Laura A. Coughlin, Nicole A. Poulides, Parastoo Sabaeifard, Suzette N. Palmer, Aidan C. Morrill, , Andrew Young Koh
This study shows that the time of day affects cancer immunotherapy efficacy through a circadian clock-dependent chemokine axis in mice.
bioRxiv · Nov 3, 2025 · PreprintImmunology