Brian Hassell

Salmonella lipopolysaccharide stimulates uptake of long-chain fatty acids in the small intestine

This study shows Salmonella LPS enhances fatty acid uptake in the mouse intestine via CD36 and myeloid TLR4, linking microbial sensing to lipid absorption and host defense.

The gut microbiota directs vitamin A flux to regulate intestinal T cell development

This paper shows the gut microbiota regulates intestinal T cell development by directing vitamin A flux through a sequential pathway involving epithelial, myeloid, and T cells.

Epithelial sensing of vitamin A shapes intestinal antimicrobial defense

This study shows dietary vitamin A enhances intestinal antimicrobial defenses by promoting REG3 lectin and defensin expression through retinoic acid receptor signaling.

Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis

This study shows that the time of day affects cancer immunotherapy efficacy through a circadian clock-dependent chemokine axis in mice.

Translational control of innate barrier defense by the gut microbiota

The gut microbiota enhances translation of innate barrier defense proteins through HDAC5-mediated activation of mTORC1 signaling.