Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8
Makis Tzioras, Michael J. D. Daniels, Caitlin Davies, Paul S. Baxter, Declan King, Sean McKay, Balazs Viktor Varga, Karla Popovic, Madison Hernandez, Anna J. Stevenson, Jack Barrington, Elizabeth Drinkwater, Julia Borella, Rebecca K. Holloway, Jane Tulloch, , Tara L. Spires‐Jones
The paper shows human astrocytes and microglia ingest more synapses in Alzheimer's disease via MFG-E8, and inhibiting MFG-E8 reduces this ingestion in cultured cells.
Cell Reports Medicine · Aug 30, 2023Peer-reviewedNeuroscience