Barry W. McColl

ABERRANT HIPPOCAMPAL NEUROGENESIS IS A CONSERVED RESPONSE TO STROKE IN MICE: A MULTI-CENTER MULTIMODEL STUDY

This study shows that stroke increases hippocampal neurogenesis but leads to maladaptive morphological features in newborn neurons across multiple mouse stroke models.

Mononuclear myeloid cells mount an adaptive protective response to intracerebral haemorrhage by activation of NRF2

The paper identifies NRF2 activation in mononuclear myeloid cells as a protective response to intracerebral haemorrhage, showing its therapeutic potential through modulation of interferon pathways.

Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study

This study evaluates cognitive outcomes after stroke in mice using multiple models and tests, finding inconsistent results and highlighting challenges in pre-clinical stroke cognition research.

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process.

The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity

This study examines how stroke alters myeloid cell composition and phenotypes in the brain, linking changes to cell origin, spatial organization, and brain connectivity.

Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's Disease

This study investigates the sex-specific role of Cst7 in microglia in an amyloid-driven Alzheimer's Disease model, finding sexually dimorphic effects on endolysosomal function and inflammation.

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

The paper shows human astrocytes and microglia ingest more synapses in Alzheimer's disease via MFG-E8, and inhibiting MFG-E8 reduces this ingestion in cultured cells.

Defining the pig microglial transcriptome reveals their core signature, regional heterogeneity, and similarity with humans

The paper defines the pig microglial transcriptome, identifies a core signature of 365 genes, reveals regional heterogeneity, and shows greater similarity between pig and human microglia than pig and mouse.

Random forest modelling of neuropathological features identifies microglial activation as an accurate pathological classifier of C9orf72-related amyotrophic lateral sclerosis

The paper uses random forest modelling to identify microglial activation as a key classifier for C9orf72-related ALS and shows spatial FUS staining changes predict disease status.

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

This study compares DNA methylation signatures of ageing and inflammation in blood and brain tissues, finding divergent correlations and a link between epigenetic age acceleration and microglial burdens in the hippocampus.

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant-negative impact on CSF1R signaling.

This study investigates a kinase-dead Csf1r mutation in mice, showing it causes dominant-negative effects on CSF1R signaling and impacts macrophage development and brain microglia.

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

The paper develops an epigenetic CRP score to assess chronic inflammation and its link to cognitive ability, finding it more consistently associated with cognition than serum CRP across two cohorts.

Myeloid cell and transcriptome signatures associated with inflammation resolution in a model of self-limiting acute brain inflammation

The paper describes a model of self-limiting acute brain inflammation and identifies gene networks associated with inflammation resolution.

A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer’s disease

The paper defines a core transcriptional signature of human microglia through meta-analysis and shows its utility in identifying region-specific alterations in Alzheimer’s disease.