Author

Michael J. D. Daniels

UK Dementia Research InstituteORCID 0000-0001-7489-5626Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

Barry W. McColliD· 3 shared Jack BarringtoniD· 2 shared Makis TziorasiD· 2 shared Tara L. Spires‐JonesiD· 2 shared Alejandro J. BrenesiD· 1 shared Alice Drake· 1 shared Amy F. LloydiD· 1 shared An Snellinx· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersNeuroscience

Barry W. McCollORCID

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4 papers

Recent·Most cited

NeuroscienceCell ReportsPeer-reviewedOct 25, 2024

Deep proteomic analysis of human microglia and model systems reveal fundamental biological differences of in vitro and ex vivo cells

Amy F. Lloyd, Anna Martínez‐Muriana, Emma Davis…·Andrew J.M. Howden

The paper compares proteomic profiles of human and mouse microglia from different sources, revealing significant differences between in vitro and ex vivo cultures.

37 citationstop 3%

humanmouse

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NeuroscienceeLifePeer-reviewedNov 6, 2023

Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's Disease

Michael J. D. Daniels, Lucas Lefèvre, Stefan Szymkowiak…·Barry W. McColl

This study investigates the sex-specific role of Cst7 in microglia in an amyloid-driven Alzheimer's Disease model, finding sexually dimorphic effects on endolysosomal function and inflammation.

30 citations

mousebulk RNA-seq

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NeuroscienceCell Reports MedicinePeer-reviewedAug 30, 2023

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

Makis Tzioras, Michael J. D. Daniels, Caitlin Davies…·Tara L. Spires‐Jones

The paper shows human astrocytes and microglia ingest more synapses in Alzheimer's disease via MFG-E8, and inhibiting MFG-E8 reduces this ingestion in cultured cells.

107 citationstop 1%

humanproteomics

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NeuroscienceThe Journal of PathologyPeer-reviewedSep 7, 2022

Random forest modelling of neuropathological features identifies microglial activation as an accurate pathological classifier of C9orf72-related amyotrophic lateral sclerosis

Olivia M. Rifai, James Longden, Judi O’Shaughnessy…·Jenna M. Gregory

The paper uses random forest modelling to identify microglial activation as a key classifier for C9orf72-related ALS and shows spatial FUS staining changes predict disease status.

21 citations

humanspatial transcriptomics

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