Author

Sean McKay

UK Dementia Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Giles E. HardinghamiD· 3 shared Paul S. BaxteriD· 3 shared Barry W. McColliD· 2 shared Colin SmithiD· 2 shared Jack BarringtoniD· 2 shared Jing QiuiD· 2 shared Owen DandoiD· 2 shared Xin HeiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Giles E. HardinghamORCID

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3 papers

Recent·Most cited

Mononuclear myeloid cells mount an adaptive protective response to intracerebral haemorrhage by activation of NRF2

James JM Loan, Jing Qiu, Jack Barrington, Paul S. Baxter, Sean McKay, Caoimhe Kirby, Xin He, Christine Lerpiniere, Karina McDade, Meryam Beniazza, Jamie McQueen, Friederike Schaper, Yihui Cheng, Bethany Geary, Owen Dando, , Giles E. Hardingham

The paper identifies NRF2 activation in mononuclear myeloid cells as a protective response to intracerebral haemorrhage, showing its therapeutic potential through modulation of interferon pathways.

bioRxiv · May 20, 2026 · PreprintNeuroscience

Astrocytes transform the transcriptomic and epigenetic landscape of developing cortical neurons to promote activity via intrinsic excitability control

Alison Todd, Jing Qiu, Kyle S. Wardlaw, Kahyee Hor, Sean McKay, Philip Hasel, Xin He, Deepali Vasoya, Mosi Li, Mandy Drake, Owen Dando, Peter C. Kind, Paul S. Baxter, David J. A. Wyllie, Giles E. Hardingham

This study shows astrocytes alter the transcriptomic and epigenetic landscape of developing cortical neurons, promoting intrinsic excitability and influencing disease-related pathways.

bioRxiv · May 19, 2026 · PreprintNeuroscience

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8

Makis Tzioras, Michael J. D. Daniels, Caitlin Davies, Paul S. Baxter, Declan King, Sean McKay, Balazs Viktor Varga, Karla Popovic, Madison Hernandez, Anna J. Stevenson, Jack Barrington, Elizabeth Drinkwater, Julia Borella, Rebecca K. Holloway, Jane Tulloch, , Tara L. Spires‐Jones

The paper shows human astrocytes and microglia ingest more synapses in Alzheimer's disease via MFG-E8, and inhibiting MFG-E8 reduces this ingestion in cultured cells.

Cell Reports Medicine · Aug 30, 2023Peer-reviewedNeuroscience