Dynamics of ML-based Morphological Features Indicate a Shear Stress-Dependent Bifurcation of hiPSC-Derived Endothelial Cell States
Erin Angelini, Chantelle L. Leveille, Serge E. Parent, Rebecca J. Zaunbrecher, Tiffany Barszczewski, Julie C. Dixon, Fatwir S. Mohammed, Benjamin Morris, Jessica S. Yu, Joy Arakaki, Renske J. Dupar, Jacqueline H. Edmonds, Erik A. Ehlers, Clare Ruth Gamlin, Maxwell J. Hedayati, , Matheus Palhares Viana
The paper uses ML to analyze morphological dynamics of hiPSC-derived endothelial cells under shear stress, identifying a bifurcation between two stable cell states.
bioRxiv · Jul 11, 2026 · PreprintBiophysics