The paper uses ML to analyze morphological dynamics of hiPSC-derived endothelial cells under shear stress, identifying a bifurcation between two stable cell states.

bioRxiv · Jul 11, 2026 · PreprintBiophysics

A human induced pluripotent stem (hiPS) cell model for the holistic study of epithelial to mesenchymal transitions (EMTs)

Caroline Hookway, Antoine Borensztejn, Leigh K. Harris, Tiffany Barszczewski, Sara G. Carlson, Gökhan Dalgin, Suraj Mishra, Ellen M. Adams, Julie C. Dixon, Renske J. Dupar, Jacqueline H. Edmonds, Erik A. Ehlers, Alexandra J. Ferrante, Margaret A. Fuqua, Clare Ruth Gamlin, , Susanne M. Rafelski

The paper presents a hiPS cell model to study EMTs by comparing 2D and 3D cultures, measuring changes in cell function, markers, organization, and environment.

Nature Methods · Jun 15, 2026Peer-reviewedCell Biology

Colony context and size-dependent compensation mechanisms give rise to variations in nuclear growth trajectories

Julie A. Cass, Christopher L. Frick, Chantelle L. Leveille, Philip Garrison, P. A. Lee, Saurabh S. Mogre, Benjamin Morris, Nivedita Nivedita, Ritvik Vasan, Jianxu Chen, Cameron L. Fraser, Clare Ruth Gamlin, Leigh K. Harris, Melissa C. Hendershott, Graham T. Johnson, , Susanne M. Rafelski

The paper analyzes nuclear growth variations in hiPS cell colonies, finding context-dependent and inherited mechanisms shaping growth trajectories.

Cell Systems · May 1, 2025Peer-reviewedCell Biology