Dickkopf1 is a Novel Endogenous Ligand for priming NLRP3 Inflammasome in Macrophages via TLR4
Theingi Aung, SuJeong Song, Joyce Kasongo, Hisashi Harada, Shijun Zhang, Octavian Henegariu, Wook‐Jin Chae
This study identifies DKK1 as a novel endogenous ligand that primes macrophages via TLR4 to activate NLRP3 inflammasome and induce pyroptosis, distinct from LPS signaling.
The Journal of Immunology · Feb 1, 2026Peer-reviewedImmunology