Hisashi Harada

This study shows that combining sacituzumab govitecan with the senolytic ABT-263 effectively overcomes chemoresistance in HNSCC by targeting senescent cells.

This paper shows that combining proteasome inhibitors with lysosome-targeted degradation enhances cancer cell death by exploiting an adaptive autophagy response.

This study identifies DKK1 as a novel endogenous ligand that primes macrophages via TLR4 to activate NLRP3 inflammasome and induce pyroptosis, distinct from LPS signaling.

This study shows proteasome inhibitors are more effective against NSCLC cells with mutant p53 by inducing oxidative stress and mitochondrial apoptosis, suggesting a new therapeutic strategy.