Joyce Rigal

Photoaffinity enabled transcriptome-wide identification of splice modulating small molecule-RNA binding events in native cells

The paper identifies RNA targets of splice modulating small molecules using photoaffinity labeling and validates binding sites with cellular SHAPE-MaP.

Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila

This study shows that artificially stimulating retrotransposon activity in Drosophila reduces lifespan and accelerates some aging phenotypes, with dFOXO partially rescuing these effects.