Michael T. Marr

The intrinsically disordered N-terminal region of eIF5B nucleates RNA-driven phase separation

This study shows that the intrinsically disordered N-terminal region of eIF5B drives RNA-driven phase separation in vitro and validates this in cells.

Acute EIF4G1 depletion reveals transcript-wide determinants of initiation factor dependence and activates initiation-specific ribosome quality control

The paper acutely depletes EIF4G1 in human cells and identifies transcript-specific effects on translation and ribosome quality control.

Structure-informed mutagenesis identifies a conserved region critical for mouse insulin receptor 5'UTR IRES function

The Insulin receptor and Insulin like growth factor receptor 5 UTRs support translation initiation independently of eIF4G1

The paper shows that the 5' UTRs of Insr and Igf1r transcripts support translation initiation independently of eIF4G1 in both in vitro and cellular settings.

The small RNA landscape is stable with age and resistant to loss of dFOXO signaling in Drosophila

The paper examines age-related changes in small RNA abundance and RISC loading in Drosophila, finding stability in small RNA levels but age-related effects on miRNA RISC loading.

Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila

This study shows that artificially stimulating retrotransposon activity in Drosophila reduces lifespan and accelerates some aging phenotypes, with dFOXO partially rescuing these effects.