Sebastián Kadener

The paper identifies non-canonical circadian oscillators in Drosophila neurons that exhibit molecular rhythms despite lacking core clock genes.

The paper examines how neuronal development and different stimulation modalities affect activity-dependent gene expression in neurons.

This study shows mechanical compression induces tissue-like multicellularity in haloarchaea, forming structures with distinct molecular and mechanical features similar to eukaryotic tissues.

This study shows circRNAs are highly stable in the aging fly brain and can indicate age and environmental experience.

The paper identifies a gene expression program in Drosophila neurons that is activated by neuronal inactivity rather than activity, involving Pura and Toy transcription factors.

The paper identifies circadian gene expression patterns in Drosophila using single-cell and bulk RNA-seq, revealing three mechanisms for generating daily gene expression rhythms.

The paper shows that ROW cooperates with BEAF-32 to regulate long-range transcription through chromatin loops at TAD boundaries.

This study shows that artificially stimulating retrotransposon activity in Drosophila reduces lifespan and accelerates some aging phenotypes, with dFOXO partially rescuing these effects.

This study shows that SARS-CoV-2 Nsp14 alters the host transcriptome, splicing, and circRNA levels, with IMPDH2 mediating these effects through GTP regulation.

The paper identifies a splicing program in neurons of Drosophila and mammals, showing how it evolves independently in different species to regulate ion channels and neuronal activity.

The paper identifies posttranscriptional mechanisms, specifically involving CPSF6 and EIF2S1, that underlie circadian temperature compensation in U-2 OS cells.

This study develops and optimizes CRISPR-Cas13 tools for RNA knockdown in Drosophila cells, improving efficiency and reducing toxicity.

This paper describes a method to specifically knock down circRNAs in vivo and shows that circRNA downregulation affects fly development and transcriptome.

This paper introduces a comprehensive pipeline for circRNA annotation and quantification, showing improved accuracy and sensitivity over existing methods.

This study shows that temperature changes alter the splicing of the timeless gene in Drosophila, affecting TIM protein levels and activity through temperature-sensitive splicing isoforms.

This study identifies PSI as a regulator of circadian period in Drosophila by modulating thermosensitive alternative splicing of timeless.

This paper develops a shRNA-based strategy to knock down circMbl in Drosophila, revealing its functional roles in development, behavior, and synaptic function.