Specificity and exon target space of splicing modifying compounds
Felina Lenkeit, Judith Knehr, Marc Altorfer, Andrea Byrnes, Wenjing Li, Jack Hsiao, Connie Wu, Priti V. Gaitonde, Philip R. Skaanderup, Steve Mullin, Elizaveta M. Solovyeva, Michal Pikusa, Andrew T. Krueger, Johannes Ottl, Caroline Gubser Keller, , Alejandro Reyes
This study investigates the specificity of splicing modulators by analyzing their interactions with RNA structures and demonstrates reprogramming of their specificity through genetic manipulation of the spliceosome.
DOAJ (DOAJ: Directory of Open Access Journals) · Jul 1, 2026Peer-reviewedMolecular Biology