VEGF-A/C co-stimulation, without shear stress, triggers the polarization of lymphatic microvessels
Jules Edwards, Florent Morfoisse, Baptiste Alric, Barbara H. Garmy-Susini, Yukiko T. Matsunaga, Aurélien Bancaud
This study shows that VEGF-A and VEGF-C co-stimulation induces lymphatic vessel polarization without shear stress, revealing a mechanism involving VEGFR2/VEGFR3 activation and geometrically-encoded stiffness.
bioRxiv · Aug 13, 2025 · PreprintBioengineering