G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics
Alexandra Mazharian, Ophélie Bertin, Amrita Sarkar, Johanna Augros, Alicia Bornert, Cécile Loubière, Friederike Jönsson, Juli Warwicker, W. Mark Abbott, Omer Dushek, Caroline Vayne, Lubica Rauova, Klaus Fütterer, Jérôme Rollin, Mortimer Poncz, Yotis A. Senis
This study introduces CAPRIs, bispecific antibodies that inhibit platelet activation by clustering G6B with ITAM receptors, showing effectiveness in preventing thrombus formation without causing bleeding.
bioRxiv · May 10, 2024 · PreprintCell Biology