Author

Klaus Fütterer

University of BirminghamORCID 0000-0001-7445-5372Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexandra MazharianiD· 1 shared Alicia BornertiD· 1 shared Alistair K. BrowniD· 1 shared Amrita SarkariD· 1 shared Caroline VayneiD· 1 shared Cécile Loubière· 1 shared Christos G. SavvaiD· 1 shared Friederike JönssoniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Alexandra MazharianORCID

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2 papers

Recent·Most cited

MicrobiologyMicrobiologyPeer-reviewedOct 16, 2024

CryoEM structure of the di-domain core of Mycobacterium tuberculosis polyketide synthase 13, essential for mycobacterial mycolic acid synthesis.

Hannah E. Johnston, Sarah M. Batt, Alistair K. Brown…·Klaus Fütterer

This paper reports the cryoEM structure of M. tuberculosis Pks13, revealing its homodimeric architecture and providing insights into its catalytic mechanism.

3 citations

cryo-EMexperimental assay

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Cell BiologybioRxivPreprintMay 10, 2024

G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics

Alexandra Mazharian, Ophélie Bertin, Amrita Sarkar…·Yotis A. Senis

This study introduces CAPRIs, bispecific antibodies that inhibit platelet activation by clustering G6B with ITAM receptors, showing effectiveness in preventing thrombus formation without causing bleeding.

5 citations

humanexperimental assay

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