ULK1 and ULK2 Restrain Skeletal Myofiber Growth by Balancing Protein Synthesis and Degradation
Wangkuk Son, Jordan D. Fuqua, Matthew P. Harris, Ryan J. Allen, Ana Kronemberger, Julia Hughes, Luís Gustavo Oliveira de Sousa, Lenoid Zingman, Sue C. Bodine, Benjamin F. Miller, Vitor Agnew Lira
This study shows that ULK1 and ULK2 regulate skeletal muscle growth by balancing protein synthesis and degradation, with lifelong deficiency causing hypertrophy but reduced muscle quality and function, while short-term deficiency allows hypertrophy without impairment.
bioRxiv · Sep 10, 2026 · PreprintCell Biology