Ryan J. Allen

This study shows that ULK1 and ULK2 regulate skeletal muscle growth by balancing protein synthesis and degradation, with lifelong deficiency causing hypertrophy but reduced muscle quality and function, while short-term deficiency allows hypertrophy without impairment.

This study identifies early aging-related changes in muscle MERC ultrastructure and proteome, which are reversed by exercise, suggesting potential therapeutic targets for sarcopenia.