CD4+ T cell activation is dependent on a novel form of ULK1/2-independent autophagy
Edward Corrigan, Jan van der Beek, Brenda Raud, Julia Oliverira Lima, Ann M. G. L. De Mazière, Anna Knol, Cornelieke E. G. M. Pals, Derk Amsen, Judith Klumperman, Enric Mocholí, Paul James Coffer
This study identifies a novel form of autophagy in CD4+ T cells that is independent of ULK1/2 and occurs alongside mTORC1 activation, supporting proliferation and cytokine production.
bioRxiv · May 1, 2026 · PreprintCell Biology