Jan van der Beek

This study shows that the HOPS complex recruits Rags and FLCN to lysosomal membranes, enabling non-canonical mTORC1 signaling and lysosomal biogenesis.

This study identifies a novel form of autophagy in CD4+ T cells that is independent of ULK1/2 and occurs alongside mTORC1 activation, supporting proliferation and cytokine production.

This study shows that β-catenin condensation drives the clustering of the cadherin/catenin complex and the formation of new cell-cell junctions.