Brain injury contributes to dopaminergic neurodegeneration, Lewy body pathology, and Parkinsonism preclinically with outcomes altered by T cell modulation
Colin Kelly, Julia P. Milner, Brooke A. Lester, Samantha Brindley, L. Pastor Hernández, Sahitya Ranjan Biswas, Laura B. Murdaugh, Xiaoran Wei, Michelle Lynne Olsen, Matthew W. Buczynski, Alicia M. Pickrell
This study shows that mild brain injury increases dopaminergic neurodegeneration and Lewy body pathology in mice, and that reducing T cell infiltration improves outcomes.
bioRxiv · Sep 16, 2025 · PreprintNeuroscience