Michelle Lynne Olsen

This study shows that astrocyte TrkB.T1 is essential for synapse formation and astrocyte-synapse interactions, with loss of TrkB.T1 reducing synapse density and interactions.

This study shows that Aβ deposition in meningeal arteries correlates with reduced cerebral blood flow and collateral vessel remodeling in a mouse model of AD, with sex differences in Aβ burden.

This study shows that mild brain injury increases dopaminergic neurodegeneration and Lewy body pathology in mice, and that reducing T cell infiltration improves outcomes.

The paper maps 5mC and 5hmC modifications in mouse cortical cell types using Nanopore sequencing and RNA sequencing, revealing astrocytes as a major source of 5hmC and providing a resource for methylome analysis.

This study identifies increased chondroitin sulfate proteoglycans (CSPGs) in the hippocampus and amygdala as a cause of infection-induced epilepsy, showing their role in neuronal hyperexcitability and potential as a therapeutic target.

This study identifies BDNF/TrkB.T1 signaling as critical for astrocyte morphological maturation, showing increased complexity and synaptogenesis in its presence.