Author

Samantha Brindley

Virginia Tech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alicia M. PickrelliD· 2 shared Brooke A. LesteriD· 2 shared Colin KellyiD· 2 shared Sahitya Ranjan BiswasiD· 2 shared Julia P Milner· 1 shared Julia P. Milner· 1 shared L. Pastor Hernández· 1 shared Laura B. MurdaughiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Alicia M. PickrellORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Impaired Complex I dysregulates neural/glial precursors and corpus callosum development revealing postnatal defects in Leigh Syndrome mice

Sahitya Ranjan Biswas, Porter L. Tomsick, Colin Kelly, Brooke A. Lester, Julia P Milner, Sara N. Henry, Yairis Soto, Samantha Brindley, Nicole DeFoor, Paul D. Morton, Alicia M. Pickrell

This study examines neural/glial precursor and corpus callosum development in Leigh Syndrome mice, revealing impaired Complex I function disrupts brain growth before neurodegenerative symptoms appear.

EMBO Molecular Medicine · Dec 22, 2025Peer-reviewedNeuroscience

Brain injury contributes to dopaminergic neurodegeneration, Lewy body pathology, and Parkinsonism preclinically with outcomes altered by T cell modulation

Colin Kelly, Julia P. Milner, Brooke A. Lester, Samantha Brindley, L. Pastor Hernández, Sahitya Ranjan Biswas, Laura B. Murdaugh, Xiaoran Wei, Michelle Lynne Olsen, Matthew W. Buczynski, Alicia M. Pickrell

This study shows that mild brain injury increases dopaminergic neurodegeneration and Lewy body pathology in mice, and that reducing T cell infiltration improves outcomes.

bioRxiv · Sep 16, 2025 · PreprintNeuroscience