Antagonistic small proteins enable magnesium-dependent tuning of two-component signaling
Lisa Werland, Gabriele Malengo, Wenting Liu, Julia Rinn, Karim Kholeif, Timo Glatter, Rémy Colin, Victor Sourjik, Jing Yuan
The paper shows how two small proteins, SafA and MgrB, work together with magnesium to control the PhoQ/PhoP signaling system in E. coli, enhancing sensitivity to environmental changes.
bioRxiv · Sep 28, 2026 · PreprintMicrobiology