Victor Sourjik

The paper shows how two small proteins, SafA and MgrB, work together with magnesium to control the PhoQ/PhoP signaling system in E. coli, enhancing sensitivity to environmental changes.

This study shows that a Western-style diet reprograms c-Kit⁺ secretory cells into tumor-initiating cells via microbial shifts and inflammation.

The paper shows that the ParB-CTPase fold can be repurposed as an ATPase toxin in bacterial contact-dependent growth inhibition systems, with toxic effects in both plant and animal cells.

The paper develops FRET-based c-di-GMP biosensors and applies them with FRET-To-Sort to map regulatory networks controlling c-di-GMP levels in E. coli.

This study investigates how multiple cell regulators affect curli gene expression in E. coli, identifying upstream regulators of CsgD and factors contributing to bimodal expression.

This study shows that Escherichia coli's chemotaxis pathway responds specifically to pyrimidine deoxyribonucleosides, mediated by the Tap receptor, with a narrow dynamic range suggesting indirect sensing.

This study shows that E. coli growth under near-lethal acid stress exhibits multi-phasic dynamics dependent on cell density and pH, with collective behavior enabling acid resistance.

The paper identifies ligand specificities of chemosensory receptors in the human gut microbiota, revealing key metabolites like lactate and formate as important signals.

This study uses experimental evolution to test the necessity of chemotaxis pathway components in E. coli, finding that core components are essential but some auxiliary proteins can be compensated for.

This study identifies the HflK-HflC complex as essential for aerobic respiration in E. coli by regulating IspG abundance and ubiquinone levels.

The paper shows that bacterial investment in flagellar motility is constrained by hydrodynamics and fitness costs, with E. coli strains maximizing motility under nutrient-rich conditions.

This study evolves an engineered microbial community to show how metabolic interactions increase, leading to interdependence and indirect selection for mutualism.

The paper develops a yeast communication toolkit for constructing multicellular networks with variable specificity and attenuation, demonstrating its application in logic gate-like networks and promiscuity analysis.

This paper introduces a noise tuner system in yeast to control gene expression noise by adjusting transcription and mRNA degradation rates, showing noise is mainly determined by transcription rate while mean expression is controlled by mRNA stability.

The paper characterizes noise sources in the Escherichia coli chemotaxis pathway using single-cell FRET and fluctuation-dissipation theorem analysis, revealing methylation-independent thermal fluctuations and receptor interactions contribute significantly to activity noise.