Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs
Kriti Chaplot, Lin Zhang, Julia Wessman, Miguel Rivera, Zhihui Wang, Fei Wang, Xin Duan, Pamela M. England, Iain C. Clark, Erik M. Ullian
This paper develops a method to rapidly generate ventral A9-like dopaminergic neurons from iPSCs using small molecules and Ascl1 expression, creating functional 3D organoids for Parkinson's disease research.
bioRxiv · Oct 31, 2025 · PreprintNeuroscience