Iain C. Clark

Single-cell DNA cytometry with magnetic- and fluorescence-activated bead sorting

The paper introduces magniFIND-seq, a method for single-cell DNA and RNA analysis using digital PCR and commercial sorting instruments, enabling high-purity isolation of rare cell populations.

Functional Pairing of TCR-peptide-MHC Interactomes by Single-cell Clonal Expansion

The paper develops LINC-seq to identify functional TCR-pMHC pairs by clonal expansion and deep mutational scanning, achieving high accuracy in recovering known cognate pairs and resolving co-evolutionary interactions.

The Immunophenotype and Proviral Landscape of HIV-infected CD4 T Cells During Antiretroviral Therapy

This study uses DAb-seq to analyze HIV-infected CD4 T cells on ART, revealing subset-specific differences in provirus maintenance and surface protein expression.

Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs

This paper develops a method to rapidly generate ventral A9-like dopaminergic neurons from iPSCs using small molecules and Ascl1 expression, creating functional 3D organoids for Parkinson's disease research.

Detection of astrocyte epigenetic memory in in vitro systems, experimental autoimmune encephalomyelitis and multiple sclerosis samples

The paper rebuts claims that astrocyte epigenetic memory is due to immune cell contamination, showing its existence in pure astrocyte cultures and MS samples.

Deterministic Cell Pairing with Simultaneous Microfluidic Merging and Sorting of Droplets

This paper introduces a microfluidic platform that deterministically pairs and sorts droplets containing cells, achieving high recovery of target cell pairs for studying cell crosstalk.

Microfluidics-free single-cell genomics with templated emulsification

The paper introduces PIP-seq, a microfluidics-free method for single-cell RNA sequencing that enables high-throughput, scalable, and flexible processing of samples.