Kriti Chaplot

A neuronal CRISPRi screen identifies PQLC2 as a lysosomal pH regulator controlling tau homeostasis

The paper identifies PQLC2 as a lysosomal pH regulator that affects tau homeostasis through a CRISPRi screen in iPSC-derived neurons.

Neuro-glial lipid imbalance in a Drosophila model of Amyotrophic Lateral Sclerosis 8

This study identifies lipid imbalance in a Drosophila ALS8 model, showing that VAPB activity regulates lipid homeostasis in neurons and glia.

Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs

This paper develops a method to rapidly generate ventral A9-like dopaminergic neurons from iPSCs using small molecules and Ascl1 expression, creating functional 3D organoids for Parkinson's disease research.

Sequestration of TDP-43216-414 aggregates by cytoplasmic expression of the proSAAS chaperone

This study shows that cytoplasmic proSAAS forms liquid-like condensates that sequester TDP-43 aggregates, providing cytoprotection against toxicity in yeast.

A protease protection assay for the detection of internalized alpha-synuclein pre-formed fibrils

This paper introduces a protease protection assay to distinguish internalized alpha-synuclein PFFs from surface-bound ones using TEV protease.

SOD1 activity thresholds and TOR signalling modulate VAP(P58S) aggregation via ROS-induced proteasomal degradation in a Drosophila model of Amyotrophic Lateral Sclerosis

The paper identifies SOD1, TOR signaling, and ROS as modifiers of VAP(P58S) aggregation in a Drosophila ALS model, showing proteasomal clearance via ROS-induced degradation.