Folding of mRNA-DNA origami for controlled translation and viral vector packaging
Iris Seitz, Sharon Saarinen, Julia Wierzchowiecka, Esa‐Pekka Kumpula, Boxuan Shen, Jeroen J. L. M. Cornelissen, Veikko Linko, Juha T. Huiskonen, Mauri A. Kostiainen
This study investigates how design parameters affect mRNA-DNA origami folding and translation efficiency, showing the importance of ribosome-binding sequences and demonstrating their encapsulation in virus capsids for enhanced delivery.
Advanced Materials · Feb 27, 2025Peer-reviewedBioengineering