Julian Lange

The human Y and inactive X chromosomes similarly modulate autosomal gene expression

The paper shows that the inactive X and Y chromosomes similarly affect autosomal gene expression in human cells through shared transcription factors.

De novo deletions and duplications at recombination hotspots in mouse germlines

The paper identifies deletion and duplication events caused by double cuts at recombination hotspots in mouse germlines, revealing their role in meiotic mutagenesis.

Control of meiotic double-strand-break formation by ATM: local and global views

This paper reviews ATM's role in regulating meiotic DSB numbers and distribution, discussing its evolutionary conservation and future research directions.

rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline

The paper identifies Dnmt3c as a fifth DNA methyltransferase paralog essential for retrotransposon methylation and male germline function in mice, revealing its role in meiosis and transposon repression.

Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice

This study investigates the genomic and chromatin features influencing meiotic DSB formation and repair in mice, identifying roles for PRDM9 and ATM in hotspot activity and recombination outcomes.