Daniel W. Bellott

The SHR/Akr Y chromosome reveals repeated turnover of the rat pseudoautosomal region

The paper sequences the rat Y chromosome and reveals a short pseudoautosomal region with high recombination rate and unique evolutionary features.

Post-transcriptional cross- and auto-regulation buffer expression of the human RNA helicases DDX3X and DDX3Y

The paper shows that DDX3X and DDX3Y exhibit post-transcriptional cross- and auto-regulation, buffering their expression levels in human cells.

Where is the boundary of the human pseudoautosomal region?

The paper re-examines the boundary of the human pseudoautosomal region 1 (PAR1) using genomic data and finds evidence supporting its original position, narrowing it to a 201-bp window.

The human Y and inactive X chromosomes similarly modulate autosomal gene expression

The paper shows that the inactive X and Y chromosomes similarly affect autosomal gene expression in human cells through shared transcription factors.

The human inactive X chromosome modulates expression of the active X chromosome

The paper shows that the inactive X chromosome modulates the expression of the active X chromosome in humans, affecting 38% of X-linked genes and contributing to sex differences in disease.

SHIMS 3.0: Highly efficient single-haplotype iterative mapping and sequencing using ultra-long nanopore reads

SHIMS 3.0 uses ultra-long nanopore reads to improve assembly of structurally complex genomic regions with high accuracy and reduced manual effort.

Large palindromes on the primate X Chromosome are preserved by natural selection

The paper identifies 26 conserved palindromes on the human X Chromosome and finds that natural selection preserves protein-coding gene families within them, while spacers show structural instability.

GC-biased gene conversion in X-Chromosome palindromes conserved in human, chimpanzee, and rhesus macaque

The paper shows GC-biased gene conversion drives GC content elevation in X-chromosome palindromes across human, chimpanzee, and rhesus macaque.

Dosage-sensitive functions in embryonic development drove the survival of genes on sex-specific chromosomes in snakes, birds, and mammals

The paper identifies dosage-sensitive developmental genes as key to survival on sex-specific chromosomes across snakes, birds, and mammals, showing broad expression and dosage sensitivity contribute independently to gene retention.

Locating a transgene integration site by nanopore sequencing

This paper uses nanopore sequencing to identify the integration site of a transgene in mouse genomes and provides additional insights into transgene structure and contamination.

Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution

The paper uses miRNA target site analysis to show preexisting gene dosage sensitivities influenced the evolution of mammalian and avian sex chromosomes.

Cost-effective, high-throughput, single-haplotype iterative mapping and sequencing for complex genomic structures

The paper introduces SHIMS 2.0, a cost-effective and high-throughput method for generating high-quality reference sequences from complex genomic regions.