Author

Sam E. Tischfield

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-5717-3856Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Scott KeeneyiD· 2 shared Alister P. W. FunnelliD· 1 shared Àlvaro Quintanal-VillalongaiD· 1 shared Andrea ArfèiD· 1 shared Arianna BaggioliniiD· 1 shared Arielle ElkriefiD· 1 shared Barbara Vaz de MelloiD· 1 shared Charles M. RudiniD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Scott KeeneyORCID

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4 papers

Recent·Most cited

Cancer BiologyTranslational OncologyPeer-reviewedJul 20, 2026

SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma

Emily A. Costa, Barbara Vaz de Mello, Corrin A. Wohlhieter…·Charles M. Rudin

The paper identifies SMARCA4/STK11/KEAP1 triple mutant lung adenocarcinoma as a poor prognosis subset and links it to TGF-β pathway activation.

DOI 10.1016/j.tranon.2026.102915

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintApr 21, 2023

DNA damage-induced interaction between a lineage addiction oncogenic transcription factor and the MRN complex shapes a tissue-specific DNA Damage Response and cancer predisposition

Romuald Binet, Jean‐Philippe Lambert, Markéta Tomková…·Colin R. Goding

This study shows that the transcription factor MITF interacts with the MRN complex to modulate the DNA damage response in melanoma, contributing to cancer predisposition.

3 citations

humanDNA methylation

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Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedJan 1, 2021

Structural and functional characterization of the Spo11 core complex

Corentin Claeys Bouuaert, Sam E. Tischfield, Stephen Pu…·Scott Keeney

This study characterizes the structure and function of the Spo11 core complex in S. cerevisiae, revealing its monomeric structure and DNA-binding properties related to meiotic DSB formation.

87 citationstop 3%

yeastexperimental assay

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GeneticsCell CyclePeer-reviewedAug 18, 2017

Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice

Shintaro Yamada, Seoyoung Kim, Sam E. Tischfield…·Scott Keeney

This study investigates the genomic and chromatin features influencing meiotic DSB formation and repair in mice, identifying roles for PRDM9 and ATM in hotspot activity and recombination outcomes.

57 citations

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