Osteochondrogenic Transdifferentiation of Vascular Smooth Muscle Cells and Microenvironmental Dynamics in Medial Arterial Calcification
Yasuhisa Nakao, Tomohisa Sakaue, Jumpei Ito, Mika Hamaguchi, Kayo Takahashi, Masayoshi Kukida, Fumiyasu Seike, Jun Aono, Shigemiki Omiya, Yuji Sakahashi, Morikatsu Yoshida, Masaki Wakabayashi, Manabu Shirai, Kazunori Yasuda, Katsuji Inoue, , Osamu Yamaguchi
This paper establishes an OTAC mouse model to study medial arterial calcification, identifying osteochondrogenic transdifferentiation of vascular smooth muscle cells and associated microenvironmental changes using scRNA-seq.
bioRxiv · Oct 28, 2025 · PreprintCell Biology