Author

Osamu Yamaguchi

Ehime UniversityORCID 0000-0002-7461-369XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Mika HamaguchiiD· 2 shared Tomohisa SakaueiD· 2 shared Yasuhisa NakaoiD· 2 shared Akiyasu IwaseiD· 1 shared Daisuke ShiokawaiD· 1 shared Fumiyasu SeikeiD· 1 shared Hiroki KuriharaiD· 1 shared Hironori IzutaniiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Mika HamaguchiORCID

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2 papers

Recent·Most cited

Stromal CTHRC1 protects the valvular interstitium from macrophage-associated inflammatory remodeling and calcification

Hiroshi Sakamoto, Tomohisa Sakaue, Mika Hamaguchi, Yasuhisa Nakao, Mie Kurata, Akiyasu Iwase, Hiroki Kurihara, Yosuke Kiriyama, Takuma Fukunishi, Hirotsugu Kurobe, Takashi Nishimura, Shunji Uchita, Daisuke Shiokawa, Yoshiaki Kubota, Osamu Yamaguchi, Hironori Izutani

This study identifies CTHRC1 as a protective factor in valvular interstitium that limits macrophage-driven calcification in aortic valve disease.

bioRxiv · Sep 25, 2026 · PreprintMolecular Biology

Osteochondrogenic Transdifferentiation of Vascular Smooth Muscle Cells and Microenvironmental Dynamics in Medial Arterial Calcification

Yasuhisa Nakao, Tomohisa Sakaue, Jumpei Ito, Mika Hamaguchi, Kayo Takahashi, Masayoshi Kukida, Fumiyasu Seike, Jun Aono, Shigemiki Omiya, Yuji Sakahashi, Morikatsu Yoshida, Masaki Wakabayashi, Manabu Shirai, Kazunori Yasuda, Katsuji Inoue, , Osamu Yamaguchi

This paper establishes an OTAC mouse model to study medial arterial calcification, identifying osteochondrogenic transdifferentiation of vascular smooth muscle cells and associated microenvironmental changes using scRNA-seq.

bioRxiv · Oct 28, 2025 · PreprintCell Biology