Author

Tomohisa Sakaue

Ehime UniversityORCID 0000-0001-7724-2225Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Mika HamaguchiiD· 2 shared Osamu YamaguchiiD· 2 shared Yasuhisa NakaoiD· 2 shared Akiyasu IwaseiD· 1 shared Daisuke ShiokawaiD· 1 shared Fumiyasu SeikeiD· 1 shared Hiroki KuriharaiD· 1 shared Hironori IzutaniiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Mika HamaguchiORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 25, 2026

Stromal CTHRC1 protects the valvular interstitium from macrophage-associated inflammatory remodeling and calcification

Hiroshi Sakamoto, Tomohisa Sakaue, Mika Hamaguchi…·Hironori Izutani

This study identifies CTHRC1 as a protective factor in valvular interstitium that limits macrophage-driven calcification in aortic valve disease.

DOI 10.64898/2026.09.21.753362

mousespatial transcriptomics

𝕏 PostBluesky

Cell BiologybioRxivPreprintOct 28, 2025

Osteochondrogenic Transdifferentiation of Vascular Smooth Muscle Cells and Microenvironmental Dynamics in Medial Arterial Calcification

Yasuhisa Nakao, Tomohisa Sakaue, Jumpei Ito…·Osamu Yamaguchi

This paper establishes an OTAC mouse model to study medial arterial calcification, identifying osteochondrogenic transdifferentiation of vascular smooth muscle cells and associated microenvironmental changes using scRNA-seq.

DOI 10.1101/2025.10.28.684711

𝕏 PostBluesky