Stable platelet production via the bypass pathway explains the long-term reconstitution capacity of hematopoietic stem cells
Shoya Iwanami, Toshiko Sato, Hiroshi Haeno, Longchen Xu, Keimyo Imamura, Jun Ooehara, Xun Lan, Hiromitsu Nakauchi, Shingo Iwami, Ryō Yamamoto
This study identifies a myeloid bypass pathway that supports long-term HSC reconstitution by analyzing single-cell transplantation data with a mathematical model.
iScience · Apr 29, 2025Peer-reviewedCell Biology