Ryō Yamamoto

The paper develops a single-cell transcriptomic map of cynomolgus macaque hematopoietic stem cells and progenitors, revealing molecular differences from humans and a direct differentiation pathway to megakaryocyte lineages.

This study identifies a myeloid bypass pathway that supports long-term HSC reconstitution by analyzing single-cell transplantation data with a mathematical model.

This study reveals bidirectional fate transitions between myeloid-biased and lineage-balanced hematopoietic stem cells using clonal phylogenetic tracing.

CIBER is a causal inference framework for analyzing cell state transitions, identifying key features in differentiation processes and predicting novel regulatory associations.