Visualizing single base RNA mutations in living cells through DNA nanostructure mediated amplification
Xiaoyi Ma, Musitaba Mutailifu, Ying Lin, Jian-Heng Qiu, Jun-Jie Wang, Zheng Wu, Yu-Zheng Gan, Lei Zhu, Li-Peng Hu, Qing Li, Jiamei Luo, Dong-Xue Li, Zhi-Gang Zhang
The paper introduces a DNA nanostructure-based platform for single-base RNA mutation detection in living cells, demonstrating its ability to distinguish insulin mRNAs and detect KRASG12D mutations with high specificity.
bioRxiv · Feb 15, 2026 · PreprintCell Biology